Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058.
Toshihiko NogawaNaoki KatoTakeshi ShimizuAkiko OkanoYushi FutamuraShunji TakahashiHiroyuki KoshinoHiroyuki OsadaPublished in: The Journal of antibiotics (2023)
A new decalin-containing secondary metabolite, wakodecaline C, was isolated from a fungus Pyrenochaetopsis sp. RK10-F058 by screening structurally interesting metabolites based on LC/MS profiling. The structure including the absolute configuration was determined by a combination of spectroscopic methods including NMR and mass spectrometry, chemical reaction, and calculation of ECD spectra. Wakodecaline C has unique structural features containing a tetrahydrofuran-fused decalin skeleton and tetramic acid moiety, which are connected through a double bond. The compound showed moderate cytotoxicity against HL-60 cells and antimalarial activity against the Plasmodium falciparum 3D7 strain.
Keyphrases
- plasmodium falciparum
- mass spectrometry
- induced apoptosis
- high resolution
- cell cycle arrest
- magnetic resonance
- liquid chromatography
- ms ms
- molecular docking
- single cell
- high intensity
- oxidative stress
- density functional theory
- endoplasmic reticulum stress
- cell proliferation
- capillary electrophoresis
- electron transfer
- simultaneous determination