Hiroyuki Osada

Researcher Name Resolver ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 75

Top Venues

ACS chemical biology

The Journal of antibiotics

Journal of natural products

Bioscience, biotechnology, and biochemistry

RIKEN Center for Sustainable Resource Science

This page only lists publications with an associated author ORCID identifier.

Affiliation History

RIKEN Center for Sustainable Resource Science Apr 01 2013

Japan

Director of Chemical Biology Research Group

RIKEN Apr 01 1983

Japan

Group Director

Publications

Katsuyuki Sakai, Yushi Futamura, Toshihiko Nogawa, Yuzhu Zhao, Hiroyuki Koshino, Hiroyuki Osada, Shunji Takahashi
Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23. Journal of natural products 87 (4) (2024)
Katsuyuki Sakai, Yushi Futamura, Toshihiko Nogawa, Yuzhu Zhao, Hiroyuki Koshino, Hiroyuki Osada, Shunji Takahashi
Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23. Journal of natural products (2024)
Hisayuki Komaki, Hiroshi Takagi, Shunji Takahashi, Hiroyuki Osada
Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov. Bioscience, biotechnology, and biochemistry (2024)
Katsuyuki Sakai, Yushi Futamura, Toshihiko Nogawa, Yuzhu Zhao, Hiroyuki Koshino, Hiroyuki Osada, Shunji Takahashi
Production of Kinanthraquinone D with Antimalarial Activity by Heterologous Gene Expression and Biotransformation in Streptomyces lividans TK23. Journal of natural products 87 (4) (2024)
Islam A Abdelhakim, Yushi Futamura, Yukihiro Asami, Hideaki Hanaki, Naoko Kito, Sachiko Masuda, Arisa Shibata, Atsuya Muranaka, Hiroyuki Koshino, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, Shunji Takahashi
Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity. Journal of natural products (2024)
Islam A Abdelhakim, Yushi Futamura, Yukihiro Asami, Hideaki Hanaki, Naoko Kito, Sachiko Masuda, Arisa Shibata, Atsuya Muranaka, Hiroyuki Koshino, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, Shunji Takahashi
Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity. Journal of natural products 87 (5) (2024)
Taylor Davie, Xènia Serrat, Lea Imhof, Jamie Snider, Igor Stagljar, Jennifer Keiser, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Andrew G Fraser
Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nature communications 15 (1) (2024)
Taylor Davie, Xènia Serrat, Lea Imhof, Jamie Snider, Igor Stagljar, Jennifer Keiser, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Andrew G Fraser
Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nature communications 15 (1) (2024)
Taylor Davie, Xènia Serrat, Lea Imhof, Jamie Snider, Igor Stagljar, Jennifer Keiser, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Andrew G Fraser
Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nature communications 15 (1) (2024)
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS chemical biology 18 (2) (2023)
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS chemical biology 18 (2) (2023)
Toshihiko Nogawa, Naoki Kato, Takeshi Shimizu, Akiko Okano, Yushi Futamura, Shunji Takahashi, Hiroyuki Koshino, Hiroyuki Osada
Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058. The Journal of antibiotics (2023)
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS chemical biology (2023)
Chiharu Okuda, Yuto Ueda, Makoto Muroi, Emiko Sanada, Hiroyuki Osada, Yoshihito Shiono, Ken-Ichi Kimura, Kenji Takeda, Koichiro Kawaguchi, Takao Kataoka
Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells. The Journal of antibiotics (2023)
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS chemical biology 18 (2) (2023)
Ken-Ichi Takayama, Seiji Matsuoka, Shungo Adachi, Teruki Honma, Masahito Yoshida, Takayuki Doi, Kazuo Shin-Ya, Minoru Yoshida, Hiroyuki Osada, Satoshi Inoue
Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment. PNAS nexus 2 (6) (2023)
Ken-Ichi Takayama, Seiji Matsuoka, Shungo Adachi, Teruki Honma, Masahito Yoshida, Takayuki Doi, Kazuo Shin-Ya, Minoru Yoshida, Hiroyuki Osada, Satoshi Inoue
Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment. PNAS nexus 2 (6) (2023)
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS chemical biology 18 (2) (2023)
Ken-Ichi Takayama, Seiji Matsuoka, Shungo Adachi, Teruki Honma, Masahito Yoshida, Takayuki Doi, Kazuo Shin-Ya, Minoru Yoshida, Hiroyuki Osada, Satoshi Inoue
Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment. PNAS nexus 2 (6) (2023)
Hirotaka Sato, Jun-Na Fukui, Hiroyuki Hirano, Hiroyuki Osada, Yutaka Arimura, Michiaki Masuda, Yoko Aida
Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication. Viruses 15 (1) (2022)
Marco Bürger, Kaori Honda, Yasumitsu Kondoh, Sharon Hong, Nobumoto Watanabe, Hiroyuki Osada, Joanne Chory
Crystal structure of Arabidopsis DWARF14-LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture. Plant direct 6 (9) (2022)
Duncan T Forster, Sheena C Li, Yoko Yashiroda, Mami Yoshimura, Zhijian Li, Luis Alberto Vega Isuhuaylas, Kaori Itto-Nakama, Daisuke Yamanaka, Yoshikazu Ohya, Hiroyuki Osada, Bo Wang, Gary D Baider, Charles Boone
BIONIC: biological network integration using convolutions. Nature methods 19 (10) (2022)
Nicole M Revie, Kali R Iyer, Michelle E Maxson, Jiabao Zhang, Su Yan, Caroline M Fernandes, Kirsten J Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S Shapiro, David R Andes, Gerard D Wright, Justin R Nodwell, Maurizio Del Poeta, Martin D Burke, Luke Whitesell, Nicole Robbins, Leah E Cowen
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. Nature communications 13 (1) (2022)
Hirotaka Sato, Jun-Na Fukui, Hiroyuki Hirano, Hiroyuki Osada, Yutaka Arimura, Michiaki Masuda, Yoko Aida
Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication. Viruses 15 (1) (2022)
Takeo Nakaya, Kenichi Aizawa, Yuki Taguchi, Kentaro Tsuji, Sachi Sekine, Kazuhiro Murakami, Masaji Kasai, Hirofumi Nakano, Yasumitsu Kondoh, Shingo Dan, Atsushi Yoshimori, Hiroyuki Kouji, Dai Takehara, Toru Suzuki, Hiroyuki Osada, Masayuki Murata, Akira Tanaka, Ryozo Nagai
Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor. ACS medicinal chemistry letters 13 (4) (2022)
Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada
Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS chemical biology 17 (2) (2022)
Raghu N Dhital, Abhijit Sen, Hao Hu, Rikako Ishii, Takuma Sato, Yoko Yashiroda, Hiromi Kimura, Charles Boone, Minoru Yoshida, Yushi Futamura, Hiroyuki Hirano, Hiroyuki Osada, Daisuke Hashizume, Yasuhiro Uozumi, Yoichi M A Yamada
Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald-Hartwig-Type Amination toward Bioactivity Assay. ACS omega 7 (28) (2022)
Islam A Abdelhakim, Takayuki Motoyama, Toshihiko Nogawa, Fauze Bin Mahmud, Yushi Futamura, Shunji Takahashi, Hiroyuki Osada
Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities. The Journal of antibiotics 75 (7) (2022)
Takayuki Motoyama, Yasumitsu Kondoh, Takeshi Shimizu, Teruo Hayashi, Kaori Honda, Motoko Uchida, Hiroyuki Osada
Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae . Journal of agricultural and food chemistry 70 (10) (2022)
Haicheng Liu, Santosh Panjikar, Xiang Sheng, Yushi Futamura, Chenghua Zhang, Nana Shao, Hiroyuki Osada, Hong-Bin Zou
β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet-Spengler Reactions to Tryptoline-type Alkaloids. ACS chemical biology 17 (1) (2022)
Hirotaka Sato, Jun-Na Fukui, Hiroyuki Hirano, Hiroyuki Osada, Yutaka Arimura, Michiaki Masuda, Yoko Aida
Application of the Luminescence Syncytium Induction Assay to Identify Chemical Compounds That Inhibit Bovine Leukemia Virus Replication. Viruses 15 (1) (2022)
Majid Manzoor, Makoto Muroi, Naoko Ogawa, Hiroki Kobayashi, Haruna Nishimura, Danni Chen, Opeyemi B Fasina, Jianyu Wang, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi
Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S -transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo . Food & function 13 (21) (2022)
Hamid Safizadeh, Scott W Simpkins, Justin Nelson, Sheena C Li, Jeff S Piotrowski, Mami Yoshimura, Yoko Yashiroda, Hiroyuki Hirano, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L Myers
Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical-Genetic Interactions. Journal of chemical information and modeling 61 (9) (2021)
Ken-Ichi Takayama, Teruki Honma, Takashi Suzuki, Yasumitsu Kondoh, Hiroyuki Osada, Yutaka Suzuki, Minoru Yoshida, Satoshi Inouei
Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy-Refractory Cancer Growth. Cancer research 81 (13) (2021)
Keisuke Fujiyama, Naoki Kato, Suyong Re, Kiyomi Kinugasa, Kohei Watanabe, Ryo Takita, Toshihiko Nogawa, Tomoya Hino, Hiroyuki Osada, Yuji Sugita, Shunji Takahashi, Shingo Nagano
Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons*. Angewandte Chemie (International ed. in English) 60 (41) (2021)
Mina Jang, Shuta Hara, Gun-Hee Kim, Seung Min Kim, Sangkeun Son, Mincheol Kwon, In-Ja Ryoo, Hyemin Seo, Min Jung Kim, Nam-Doo Kim, Nak-Kyun Soung, Yong Tae Kwon, Bo Yeon Kim, Hiroyuki Osada, Jae-Hyuk Jang, Sung-Kyun Ko, Jong Seog Ahn
Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6. ACS chemical biology 16 (2) (2021)
Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki, Shingo Dan, Hiroyuki Osada
Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth. ACS chemical biology 16 (11) (2021)
Takayuki Motoyama, Tomoaki Ishii, Takashi Kamakura, Hiroyuki Osada
Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism. Bioscience, biotechnology, and biochemistry 85 (10) (2021)
Julius Adam V Lopez, Toshihiko Nogawa, Yushi Futamura, Harumi Aono, Daisuke Hashizume, Hiroyuki Osada
N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647. The Journal of antibiotics 74 (7) (2021)
Mira Syahfriena Amir Rawa, Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Habibah A Wahab, Hiroyuki Osada
Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026. The Journal of antibiotics 74 (8) (2021)
Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-Ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock. Communications biology 4 (1) (2021)
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Toshihiko Nogawa, Akiko Okano, Daisuke Hashizume, Hiroyuki Osada
Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth. ACS chemical biology 16 (8) (2021)
Katsuyuki Sakai, Risa Takao, Hiroyuki Koshino, Yushi Futamura, Hiroyuki Osada, Shunji Takahashi
6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone. The Journal of antibiotics 74 (9) (2021)
Islam A Abdelhakim, Fauze Bin Mahmud, Takayuki Motoyama, Yushi Futamura, Shunji Takahashi, Hiroyuki Osada
Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94. Journal of natural products 85 (1) (2021)
Kazuko Yoshida, Yasumitsu Kondoh, Takeshi Nakano, Byambajav Bolortuya, Shintaro Kawabata, Fukumatsu Iwahashi, Eiki Nagano, Hiroyuki Osada
New Abscisic Acid Derivatives Revealed Adequate Regulation of Stomatal, Transcriptional, and Developmental Responses to Conquer Drought. ACS chemical biology 16 (8) (2021)
Nobuaki Ishihama, Seung-Won Choi, Yoshiteru Noutoshi, Ivana Saska, Shuta Asai, Kaori Takizawa, Sheng Yang He, Hiroyuki Osada, Ken Shirasu
Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway. Nature communications 12 (1) (2021)
Yoshitomo Shiroma, Go Fujita, Takuya Yamamoto, Ryou-U Takahashi, Ashutosh Kumar, Kam Y J Zhang, Akihiro Ito, Hiroyuki Osada, Minoru Yoshida, Hidetoshi Tahara
Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods. International journal of molecular sciences 21 (23) (2020)
Sho Kato, Takayuki Motoyama, Yushi Futamura, Masakazu Uramoto, Toshihiko Nogawa, Toshiaki Hayashi, Hiroshi Hirota, Akira Tanaka, Naoko Takahashi-Ando, Takashi Kamakura, Hiroyuki Osada
Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94. Bioscience, biotechnology, and biochemistry 84 (6) (2020)
Toshihiko Nogawa, Atsutaka Terai, Keita Amagai, Junko Hashimoto, Yushi Futamura, Akiko Okano, Manabu Fujie, Noriyuki Satoh, Haruo Ikeda, Teppei Kawahara, Hiroyuki Osada, Shunji Takahashi
Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues. Journal of natural products 83 (12) (2020)
Hiroki Kobayashi, Haruna Nishimura, Norio Kudo, Hiroyuki Osada, Minoru Yoshida
A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells. Bioscience, biotechnology, and biochemistry 84 (10) (2020)
Shihori Asai, Yuta Tsunematsu, Takahiro Masuya, Junnosuke Otaka, Hiroyuki Osada, Kenji Watanabe
Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete. The Journal of antibiotics 73 (10) (2020)
Tatsuro Kawamura, Yushi Futamura, Erchang Shang, Makoto Muroi, Petra Janning, Masayoshi Ueno, Julian Wilke, Shigeki Takeda, Yasumitsu Kondoh, Slava Ziegler, Nobumoto Watanabe, Herbert Waldmann, Hiroyuki Osada
Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics. Bioscience, biotechnology, and biochemistry 84 (12) (2020)
Akiko Tabuchi, Emi Fukushima-Sakuno, Kumiko Osaki-Oka, Yushi Futamura, Takayuki Motoyama, Hiroyuki Osada, Noemia Kazue Ishikawa, Eiji Nagasawa, Keisuke Tokimoto
Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes. Bioscience, biotechnology, and biochemistry 84 (5) (2020)
Kaori Sako, Yushi Futamura, Takeshi Shimizu, Akihiro Matsui, Hiroyuki Hirano, Yasumitsu Kondoh, Makoto Muroi, Harumi Aono, Maho Tanaka, Kaori Honda, Kenshirou Shimizu, Makoto Kawatani, Takeshi Nakano, Hiroyuki Osada, Ko Noguchi, Motoaki Seki
Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana. Scientific reports 10 (1) (2020)
Hiroki Kobayashi, Hideyuki Hatakeyama, Haruna Nishimura, Mutsumi Yokota, Sadafumi Suzuki, Yuri Tomabechi, Mikako Shirouzu, Hiroyuki Osada, Masakazu Mimaki, Yu-Ichi Goto, Minoru Yoshida
Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations. Nature chemical biology 17 (3) (2020)
Choong-Soo Yun, Kazuki Nishimoto, Takayuki Motoyama, Takeshi Shimizu, Tomoya Hino, Naoshi Dohmae, Shingo Nagano, Hiroyuki Osada
Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1. The Journal of biological chemistry 295 (33) (2020)
Sho Kato, Takayuki Motoyama, Masakazu Uramoto, Toshihiko Nogawa, Takashi Kamakura, Hiroyuki Osada
Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene. The Journal of antibiotics 73 (7) (2020)
Hiroaki Ikeda, Makoto Muroi, Yasumitsu Kondoh, Shumpei Ishikawa, Hideaki Kakeya, Hiroyuki Osada, Masaya Imoto
Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS chemical biology 15 (8) (2020)
Hiroyuki Osada
Special issue: Nucleoside antibiotics, polyoxin and beyond. The Journal of antibiotics 72 (12) (2019)
Keitou Shu, Naoya Iwamoto, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Hirano, Hiroyuki Osada, Hiroaki Ohno, Nobutaka Fujii, Shinya Oishi
Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors. Bioconjugate chemistry 30 (5) (2019)
Kruthi Suvarna, Kaori Honda, Makoto Muroi, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. The Journal of biological chemistry 294 (9) (2019)
Shohei Takase, Rumi Kurokawa, Yasumitsu Kondoh, Kaori Honda, Takehiro Suzuki, Teppei Kawahara, Haruo Ikeda, Naoshi Dohmae, Hiroyuki Osada, Teppei Kawahara, Tetsuo Kushiro, Minoru Yoshida, Ken Matsumoto
Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure. ACS chemical biology 14 (8) (2019)
Hiroyuki Osada
Discovery and applications of nucleoside antibiotics beyond polyoxin. The Journal of antibiotics 72 (12) (2019)
Kazuko Yoshida, Yasumitsu Kondoh, Fukumatsu Iwahashi, Takeshi Nakano, Kaori Honda, Eiki Nagano, Hiroyuki Osada
Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies. ACS chemical biology 14 (9) (2019)
Naoki Kanoh, Ayano Kawamata-Asano, Kana Suzuki, Yusuke Takahashi, Takeshi Miyazawa, Takemichi Nakamura, Takashi Moriya, Hiroyuki Hirano, Hiroyuki Osada, Yoshiharu Iwabuchi, Shunji Takahashi
An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s. Scientific reports 9 (1) (2019)
Scott W Simpkins, Raamesh Deshpande, Justin Nelson, Sheena C Li, Jeff S Piotrowski, Henry Neil Ward, Yoko Yashiroda, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L Myers
Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments. Nature protocols 14 (2) (2019)
Kazuyuki Maeda, Hinayo Ichikawa, Yuichi Nakajima, Takayuki Motoyama, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Hiroyuki Osada, Makoto Kimura
Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum. ACS chemical biology 13 (5) (2018)
Sangkeun Son, Young-Soo Hong, Yushi Futamura, Mina Jang, Jae Kyoung Lee, Kyung Taek Heo, Sung-Kyun Ko, Jung Sook Lee, Shunji Takahashi, Hiroyuki Osada, Jae-Hyuk Jang, Jong Seog Ahn
Catenulisporolides, Glycosylated Triene Macrolides from the Chemically Underexploited Actinomycete Catenulispora Species. Organic letters 20 (22) (2018)
Jun-Pil Jang, Gwi Ja Hwang, Min Cheol Kwon, In-Ja Ryoo, Mina Jang, Shunji Takahashi, Sung-Kyun Ko, Hiroyuki Osada, Jae-Hyuk Jang, Jong Seog Ahn
Pentaminomycins A and B, Hydroxyarginine-Containing Cyclic Pentapeptides from Streptomyces sp. RK88-1441. Journal of natural products 81 (4) (2018)
Naoki Kato, Toshihiko Nogawa, Ryo Takita, Kiyomi Kinugasa, Misae Kanai, Masanobu Uchiyama, Hiroyuki Osada, Shunji Takahashi
Control of the Stereochemical Course of [4+2] Cycloaddition during trans-Decalin Formation by Fsa2-Family Enzymes. Angewandte Chemie (International ed. in English) 57 (31) (2018)
Jun-Pil Jang, Gwi Ja Hwang, Mina Jang, Shunji Takahashi, Sung-Kyun Ko, Hiroyuki Osada, Jae-Hyuk Jang, Jong Seog Ahn
Aturanosides A and B, Glycosylated Anthraquinones with Antiangiogenic Activity from a Soil-Derived Streptomyces Species. Journal of natural products 81 (9) (2018)
Naoki Kato, Shogo Furutani, Junnosuke Otaka, Akira Noguchi, Kiyomi Kinugasa, Kenji Kai, Hideo Hayashi, Makoto Ihara, Shunji Takahashi, Kazuhiko Matsuda, Hiroyuki Osada
Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels. ACS chemical biology 13 (3) (2018)
Zhi-Jun Jia, Hiroshi Takayama, Yushi Futamura, Harumi Aono, Jonathan O Bauer, Carsten Strohmann, Andrey P Antonchick, Hiroyuki Osada, Herbert Waldmann
Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity. The Journal of organic chemistry 83 (13) (2018)
Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae. ACS chemical biology 12 (9) (2017)
Ammara Khalid, Hiroshi Takagi, Suresh Panthee, Makoto Muroi, Joe Chappell, Hiroyuki Osada, Shunji Takahashi
Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593. ACS synthetic biology 6 (12) (2017)

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Hiroyuki Osada