The Omicron Lineages BA.1 and BA.2 ( Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub.
Alessandra P LamarcaUeric José Borges de SouzaFilipe Romero Rebello MoreiraLuiz Gonzaga Paula de AlmeidaMariane Talon de MenezesAdrieli Barboza de SouzaAlessandro Clayton de Souza FerreiraAlexandra Lehmkuhl GerberAline Brito de LimaAna Paula de C GuimarãesAndréa Cony CavalcantiAryel B Paz E SilvaBruna Israel LimaCirley LobatoCristiane Gomes Da SilvaCristiane Pinheiro Toscano Brito MendonçaDaniel Costa QueirozDanielle Alves Gomes ZauliDiego Menezes BonfimFábio Sossai PossebonFranciano Dias Pereira CardosoFrederico Scott Varella MaltaIsabela Braga-PazJoice do Prado SilvaJorge Gomes Goulart FerreiraJucimária Dantas GalvãoLeandro Magalhães de SouzaLeonardo FerreiraLia Gonçalves PossueloLiliane Tavares de Faria CavalcanteLuige Biciati AlvimLuiz Fellype Alves de SouzaLuiza C G de Araújo E SantosRillery Calixto DiasRutilene Barbosa SouzaThaís Regina Y CastroAndreia Rosane de Moura ValimFabrício Souza CamposJoão Pessoa Araújo JúniorPriscila de Arruda TrindadeRenato Santana de AguiarRobson Michael DelaiAna Tereza Ribeiro de VasconcelosPublished in: Viruses (2023)
Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation.