Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women.
Sara Moron-LopezGuorui XiePeggy KimDavid A SiegelSulggi LeeJoseph K WongJennifer C PriceNajwa ElnachefRuth M GreenblattPhyllis C TienNadia R RoanSteven A YuklPublished in: Journal of the International AIDS Society (2021)
These results suggest tissue-specific differences in the mechanisms that govern HIV expression, with lower HIV transcription in most tissues than blood. Therapies aimed at disrupting latency, such as latency-reversing or latency-silencing agents, will be required to penetrate into multiple tissues and target different blocks to HIV transcription.
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