Intracellular trafficking kinetics of nucleic acid escape from lipid nanoparticles via fluorescence imaging.
Christina M Bailey-HytholtGregory UlinskiJulia DugasMohammed HainesMihael LazebnikPeter PiepenhagenIsidro E ZarragaAmey Bandekar
Published in: Current pharmaceutical biotechnology (2023)
Here, we demonstrated the ability to track uptake and the sub-cellular fate of LNPs containing pDNA and mRNA, enabling improved screening prior to in vivo studies which would aid in formulation optimization.