Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy.
Yuliang FengLiuyang CaiWanzi HongChunxiang ZhangNing TanMingyang WangCheng WangFeng LiuXiaohong WangJianyong MaChen GaoMohit KumarYuanxi MoQingshan GengChangjun LuoYan LinHaiyang ChenShuang-Yin WangMichael J WatsonAnil G JeggaRoger A PedersenJi-Dong FuZhao V WangGuo-Chang FanSakthivel SadayappanYigang WangSiim PauklinFeng HuangWei HuangLei JiangPublished in: Circulation (2022)
This study provided novel chromatin topology insights into DCM pathogenesis and illustrated a model whereby a single transcription factor (HAND1) reprograms the genome-wide enhancer-promoter connectome to drive DCM pathogenesis.