Pre-treatment bicarbonate levels and decongestion by acetazolamide: the ADVOR trial.
Pieter MartensFrederik H VerbruggeJeroen DauwPetra NijstEvelyne MeekersSilvio Nunes AugustoJozine M Ter MaatenLine HeylenKevin DammanAlexandre MebazaaGerasimos S FilippatosFrank RuschitzkaWai Hong Wilson TangMatthias DupontWilfried MullensPublished in: European heart journal (2023)
Acetazolamide improves decongestive response over the entire range of HCO3- levels; however, the treatment response is magnified in patients with baseline or loop diuretic-induced elevated HCO3 (marker of proximal nephron NaHCO3 retention) by specifically counteracting this component of diuretic resistance.