Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma.

Maciej SzmidtAdrian StankiewiczKaja UrbańskaSławomir JaworskiMarta KutwinMateusz WierzbickiMarta GrodzikBeata BurzyńskaMonika GóraAndre ChwalibogEwa Sawosz

Published in: BMC molecular biology (2019)

We suggest that changes in the expression of OXPHOS genes identified in our study may mediate the anti-proliferative and anti-migratory effects of graphene oxide in glioblastoma cells. However, further investigations with different cell lines, regarding expression, regulation and activity of OXPHOS genes identified in our study is necessary to elucidate the mechanism mediating the anti-proliferative and anti-migratory effects of graphene oxide in glioblastoma cells.

Keyphrases

induced apoptosis
poor prognosis
genome wide
cell cycle arrest
oxidative stress
gene expression
dna methylation
signaling pathway
cell death
binding protein
cell proliferation