BAG3 Overexpression Attenuates Ischemic Stroke Injury by Activating Autophagy and Inhibiting Apoptosis.
Xia LiuQinlian YeZhengzheng HuangXiuping LiLiping ZhangXuan LiuYun-Cheng WuUlf BrockmeierJanine GronewoldYa-Chao WangLijie RenPublished in: Stroke (2023)
Our findings indicate that BAG3 overexpression activates autophagy and inhibits apoptosis to prevent cerebral ischemia/reperfusion and hypoxia/reoxygenation injury, suggesting a potential therapeutic benefit of BAG3 expression in cerebral ischemia.
Keyphrases
- endoplasmic reticulum stress
- cerebral ischemia
- induced apoptosis
- cell death
- subarachnoid hemorrhage
- signaling pathway
- oxidative stress
- cell cycle arrest
- brain injury
- blood brain barrier
- cell proliferation
- pi k akt
- poor prognosis
- transcription factor
- atrial fibrillation
- endothelial cells
- long non coding rna
- binding protein