Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells.

Antonio Celentano Tami YapRita PaoliniCallisthenis YiannisMichiko MiramsKendrick Koo Michael J McCullough Nicola Cirillo

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

We have demonstrated, for the first time, that MMP2 inhibition affects oral cancer cells ability to survive, migrate and invade in vitro. Differences between MMP2 expression in normal and malignant tissues varied. Further research on the role of MMP2 in OSCC and novel mechanisms to inhibit MMP2-dependent pathways should be encouraged.

Keyphrases

cell migration
induced apoptosis
poor prognosis
gene expression
cell cycle arrest
signaling pathway
cell proliferation