TIGIT expression in renal cell carcinoma infiltrating T cells is variable and inversely correlated with PD-1 and LAG3.
Oscar PeralesLucia B JilaveanuAdebowale J AdeniranDavid G SuMichael E HurwitzDavid A BraunHarriet M KlugerDavid A SchoenfeldPublished in: Cancer immunology, immunotherapy : CII (2024)
Our findings support careful evaluation of TIGIT expression on T cells in primary or metastatic RCC specimens for patients who may be treated with TIGIT-targeting antibodies, as increased TIGIT positivity might be associated with a greater likelihood of response to therapy.