Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β-common receptor in mice with cerebral ischemic stroke.

Rong-Liang WangZhen-Hong YangYu-You HuangYue HuYi-Lin WangFeng YanYang-Min ZhengZi-Ping HanJun-Fen FanZhen TaoHai-Ping ZhaoSi-Jie LiYu-Min Luo

Published in: CNS neuroscience & therapeutics (2024)

ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role of ARA290 in ischemic stroke intervention.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
high fat diet induced
atrial fibrillation
randomized controlled trial
brain injury
blood brain barrier
white matter
resting state
type diabetes
metabolic syndrome
multiple sclerosis
oxidative stress
functional connectivity
adipose tissue