Pueraria tuberosa extract inhibits iNOS and IL-6 through suppression of PKC-α and NF-kB pathway in diabetes-induced nephropathy.
Rashmi ShuklaSomanshu BanerjeeYamini Bhusan TripathiPublished in: The Journal of pharmacy and pharmacology (2018)
This study suggested that the nephroprotective effect of PTY-2r is possibly due to downregulation of PKC-α and NF-kB pathway and normalizing the expression of inflammatory cytokines and iNOS in the kidney of DN rats.
Keyphrases
- signaling pathway
- oxidative stress
- lps induced
- pi k akt
- type diabetes
- poor prognosis
- nitric oxide synthase
- nuclear factor
- diabetic rats
- cardiovascular disease
- high glucose
- cell proliferation
- nitric oxide
- glycemic control
- inflammatory response
- binding protein
- endothelial cells
- drug induced
- anti inflammatory
- skeletal muscle
- toll like receptor
- insulin resistance
- weight loss