Eliciting an immune-mediated antitumor response through oncolytic herpes simplex virus-based shared antigen expression in tumors resistant to viroimmunotherapy.
Mohammed G GhonimeUksha SainiMichael C KellyJustin C RothPin-Yi WangChun-Yu ChenKatherine MillerIlse Hernandez-AguirreYeaseul KimXiaokui MoJoseph R StanekTimothy P CripeElaine MardisKevin A CassadyPublished in: Journal for immunotherapy of cancer (2022)
Our results suggest that this flexible viral-based platform enables immune recognition of the shared TAA and improves the immune-therapeutic response, thus making it well suited for low-mutational load tumors.