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Robust expression of tumor suppressor miRNA's let-7 and miR-195 detected in plasma of Saudi female breast cancer patients.

Amal QattanHaya IntabliWafa AlkhayalChafica EltabacheTaher TweigieriSuad Bin Amer
Published in: BMC cancer (2017)
While studies have indicated that the restoration of let-7 and miR-195 may be a potential therapy for cancer, these results suggested that tumor cells may selectively export hsa-miR-195 and let-7 miRNAs thereby neutralizing their potential therapeutic effect. However, in order to facilitate earlier detection of breast cancer, blood based screening of hsa-miR-195 and let-7 may be beneficial in a female patient cohort.
Keyphrases
  • cell proliferation
  • long non coding rna
  • long noncoding rna
  • poor prognosis
  • squamous cell carcinoma
  • young adults
  • human health
  • lymph node metastasis
  • dengue virus
  • loop mediated isothermal amplification