Evolution of spatial risk of malaria infection after a pragmatic chemoprevention program in response to severe flooding in rural western Uganda.

The findings enhance our understanding not only of the spatial evolution of malaria risk after flooding, but also in the context of an effective intervention. The results provide a "proof-of-concept" for programs aiming to prevent malaria outbreaks after flooding using a combination of interventions. Further study of mitigation strategies - and particularly studies of implementation - is urgently needed.