The prognostic significance of weight loss in chronic obstructive pulmonary disease-related cachexia: a prospective cohort study.
Hoi Yee KwanMaddocks MatthewClaire M NolanSarah E JonesSuhani PatelRuth E BarkerSamantha S C KonMichael I PolkeyPaul CullinanWilliam D-C ManPublished in: Journal of cachexia, sarcopenia and muscle (2019)
Despite the low prevalence of cachexia and pre-cachexia, both confer increased mortality risk in COPD, driven by the unintentional weight loss component. Our data suggest that low FFMI without concurrent weight loss may not confer the poor prognosis as previously reported for this group. Weight loss should be regularly monitored in practice and may represent an important target in COPD management. We propose the incorporation of weight monitoring into national and international COPD guidance.
Keyphrases
- weight loss
- poor prognosis
- bariatric surgery
- chronic obstructive pulmonary disease
- roux en y gastric bypass
- gastric bypass
- lung function
- long non coding rna
- quality improvement
- primary care
- glycemic control
- squamous cell carcinoma
- electronic health record
- cystic fibrosis
- physical activity
- metabolic syndrome
- skeletal muscle
- artificial intelligence