Computational analysis of a microRNA signature for poor prognosis suggests a microRNA-controlled stemness pathway in paediatric acute leukaemia.
Stefan J ErkelandPublished in: British journal of haematology (2023)
Esperanza-Cebollada E., et al. found a group of 24 microRNAs, to be differentially expressed between two groups of paediatric acute myeloid leukaemia (AML) cases with distinct outcomes. The main target of this microRNA signature is SOCS2, a gene that controls stemness. The results of this study may open doors for further investigation of the role for microRNAs in poor prognostic paediatric AML. Commentary on: Esperanza-Cebollada et al. A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia. Br J Haematol 2023 (Online ahead of print). doi: 10.1111/bjh.18746.
Keyphrases
- poor prognosis
- liver failure
- acute myeloid leukemia
- intensive care unit
- stem cells
- emergency department
- respiratory failure
- epithelial mesenchymal transition
- drug induced
- long non coding rna
- end stage renal disease
- genome wide
- bone marrow
- dendritic cells
- social media
- newly diagnosed
- ejection fraction
- chronic kidney disease
- allogeneic hematopoietic stem cell transplantation
- metabolic syndrome
- healthcare
- peritoneal dialysis
- type diabetes
- adipose tissue
- dna methylation
- cancer stem cells
- immune response
- acute lymphoblastic leukemia
- prognostic factors
- patient reported
- health information