Increased expression of ATP-binding cassette transporters in enfortumab vedotin-resistant urothelial cancer.

Mariko KotonoToshiki KijimaAtsuko Takada-OwadaNaoya OkuboRyo KurashinaHidetoshi KokubunToshitaka UematsuKohei TakeiKazuyuki IshidaTakao Kamai

Published in: IJU case reports (2024)

Decreased nectin-4 expression and increased ATP-binding cassette transporter expression are potential factors in the development of enfortumab vedotin resistance in urothelial carcinoma. Immunohistochemical evaluation of these proteins may aid in predicting treatment efficacy.

Keyphrases

poor prognosis
binding protein
hodgkin lymphoma
long non coding rna
squamous cell carcinoma
risk assessment
high grade
transcription factor