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Reduced expression of DNA repair genes and chemosensitivity in 1p19q codeleted lower-grade gliomas.

Lei TangLu DengHarrison X BaiJames SunNatalie NealeJing WuYinyan WangKen ChangRaymond Y HuangPaul J ZhangXuejun LiBo XiaoYa CaoYongguang TaoLi Yang
Published in: Journal of neuro-oncology (2018)
Our results suggest that reduced expression of DNA repair genes on chromosome arms 1p and 19q may account for the increased chemosensitivity of LGGs with 1p19q codeletion.
Keyphrases
  • dna repair
  • dna damage
  • poor prognosis
  • dna damage response
  • genome wide
  • high grade
  • bioinformatics analysis
  • binding protein
  • genome wide identification
  • long non coding rna
  • dna methylation
  • gene expression