Purification and antioxidant and anti-Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola.

Kang ZuoKaijing TangYue LiangYifan XuKangliang ShengXiaowei KongJingmin WangFenfang ZhuXiangdong ZhaYongzhong Wang

Published in: Journal of the science of food and agriculture (2020)

The SePSP had strong concentration-dependent antioxidant activity in vitro and effectively alleviated DSS-induced UC in mice. The in vivo therapeutic efficacy in DSS-induced UC may be mediated by modulating the expression of inflammatory cytokines and inhibiting oxidative stress. The findings provide a scientific rationale for the use of bioactive nutraceuticals from sanghuang mushrooms to develop functional foods for the prevention and treatment of UC. © 2020 Society of Chemical Industry.

Keyphrases

oxidative stress
diabetic rats
high glucose
signaling pathway
poor prognosis
dna damage
drug induced
endothelial cells
induced apoptosis
long non coding rna
skeletal muscle
high fat diet induced
replacement therapy