Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.

Hongqiang Wang Baojuan Zhu Lei Yu Qiang Li Shenqian Li Peitao Wang Tao Jing Tongyi Men

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Lycopene improved the hypoxia-induced testicular injury by inhibiting the expression of PROK2 and decreasing levels of IL-1β and IL-2, which might show us a novel and promising treatment for varicocele testicular injury.

Keyphrases

poor prognosis
germ cell
signaling pathway
oxidative stress
long non coding rna
combination therapy
young adults
replacement therapy
childhood cancer