PD-L1 regulates tumor proliferation and T-cell function in NF2-associated meningiomas.
Ying WangChao ZhangMinjun YanXin MaLairong SongBo WangPeng LiPi-Nan LiuPublished in: CNS neuroscience & therapeutics (2024)
Targeting PD-L1 could be helpful for restoring the function of tumor-infiltrating lymphocytes and inducing apoptosis to inhibit tumor proliferation in NF2-associated meningiomas. Dissecting the mechanisms of the PD-L1-driven tumorigenesis of NF2-associated meningioma will help to improve our understanding of the mechanisms underlying tumor progression and could facilitate further refinement of current therapies to improve the treatment of NF2 patients.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- oxidative stress
- nuclear factor
- end stage renal disease
- chronic kidney disease
- cell cycle arrest
- ejection fraction
- newly diagnosed
- inflammatory response
- poor prognosis
- endoplasmic reticulum stress
- prognostic factors
- peritoneal dialysis
- peripheral blood
- cell proliferation
- cancer therapy
- combination therapy
- patient reported