Influence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis.

Tobias TägerLutz FrankensteinDan AtarStefan AgewallNorbert FreyMorten GrundtvigAndrew L ClarkJohn G F ClelandHanna Fröhlich

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)

Our data point towards a class-effect of SGLT2i on mortality and renal outcomes. However, non-selective SGLT2i such as sotagliflozin may be superior to highly selective SGLT2i in terms of HF outcomes.

Keyphrases

systematic review
optic nerve
electronic health record
meta analyses
risk factors
randomized controlled trial
adipose tissue
big data
metabolic syndrome
machine learning
binding protein
glycemic control
optical coherence tomography
case control
acute heart failure
structural basis