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Proteogenomic Identification and Analysis of KIF5B as a Prognostic Signature for Hepatocellular Carcinoma.

Lishuang QiYilong TanYunfei ZhouYihong DongXun YangShuyuan ChangLei YuDabin Liu
Published in: Current gene therapy (2024)
Our findings have suggested KIF5B protein to function as a novel prognostic biomarker in HCC. KIF5B expression has been found to activate the AKT/mTOR pathway and reprogram triglyceride metabolism, leading to HCC development. Targeting KIF5B may be an effective strategy in the clinical treatment of HCC.
Keyphrases
  • cell proliferation
  • poor prognosis
  • signaling pathway
  • binding protein
  • cancer therapy
  • amino acid
  • long non coding rna
  • combination therapy