On resin synthesis of phosphoethanolamine cellulose.

Phosphoethanoamine (pEtN) cellulose is a chemically modified cellulose present in some bacterial biofilms. To deepen our understanding of this biopolymer and its biological function, access to chemically defined pEtN-cellulose oligosaccharides is desirable. Herein, we report an on resin protocol for the fast synthesis of tailor-made pEtN-celluloses. The cellulose backbone is prepared by automated glycan assembly and then specifically functionalized with pEtN groups, allowing for access to a collection of ten pEtN-cellulose oligomers with different amount and pattern of pEtN.