Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-Targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma.

Wesley YipDaniel D SjobergLucas M NogueiraAndrew T TraceyRicardo G AlvimPeter A ReiszQuinlan DemacNicole E BenfanteRand W Vanden BergKwanghee KimHikmat Al-AhmadieOscar LinBernard H BochnerGuido DalbagniS Machele DonatEugene J PietzakA Ari HakimiDavid B SolitAvigdor ScherzDean F BajorinJonathan A Coleman

Published in: The Journal of urology (2023)

VTP with WST-11 has an acceptable safety profile with strong potential as an effective, kidney-sparing endoscopic management option for UTUC. The recently initiated multi-center phase 3 ENLIGHTED trial (NCT04620239) is expected to provide further evidence on this therapy.

Keyphrases

phase iii
study protocol
cancer therapy
phase ii
clinical trial
ultrasound guided
randomized controlled trial
open label
robot assisted
drug delivery
minimally invasive
risk assessment
cell therapy