iPSC-Derived Astrocytes and Neurons Replicate Brain Gene Expression, Epigenetic, Cell Morphology and Connectivity Alterations Found in Autism.
Hamid Mostafavi AbdolmalekyReza AlamShabnam NohesaraRichard C DethJin-Rong ZhouPublished in: Cells (2024)
Autism-associated expression/epigenetic alterations in iPSC-derived cells replicated those reported in the literature, making them appropriate surrogates to study disease pathogenesis or patient-specific therapeutics.
Keyphrases
- gene expression
- dna methylation
- autism spectrum disorder
- resting state
- intellectual disability
- induced apoptosis
- white matter
- poor prognosis
- functional connectivity
- systematic review
- cell cycle arrest
- single cell
- small molecule
- spinal cord
- cell therapy
- oxidative stress
- spinal cord injury
- mesenchymal stem cells
- multiple sclerosis
- cerebral ischemia
- brain injury
- blood brain barrier