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Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix.

Maria-Alexandra PaunMihai-Virgil NichitaVladimir-Alexandru PaunViorel-Puiu Paun
Published in: Gels (Basel, Switzerland) (2022)
Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix.
Keyphrases
  • electron microscopy
  • drug delivery
  • deep learning
  • wound healing
  • optical coherence tomography
  • convolutional neural network
  • atomic force microscopy
  • cross sectional
  • mass spectrometry
  • magnetic resonance