Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.

Matteo Di GiovannantonioBenjamin Howell Lole HarrisPing ZhangIsaac Kitchen-SmithLingyun XiongNatasha SahgalGiovanni StracquadanioMarsha WallaceSarah BlagdenSimon LordDavid HarrisAdrian H L HarrisFrancesca M BuffaGareth L Bond

Published in: Journal of medical genetics (2020)

Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.

Keyphrases

genome wide
papillary thyroid
copy number
squamous cell
body composition
dna methylation
endothelial cells
bioinformatics analysis
squamous cell carcinoma
childhood cancer
transcription factor
pluripotent stem cells