Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study.

Hanna den BakkerMichael S SidorovZheng FanDavid J LeeLynne M BirdCatherine J ChuBenjamin D Philpot

Published in: Molecular autism (2018)

We demonstrate two quantitative readouts of dysregulated sleep composition in children with AS-gamma coherence and spindles-and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated in children with AS.

Keyphrases

functional connectivity
resting state
young adults
clinical trial
high resolution
sleep quality
working memory
randomized controlled trial
social media
climate change
depressive symptoms
phase ii