Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions.

A MilosavljevićLjiljana ĐukićB ToljićJ MilašinB DŽeletovićB BrkovićJelena Roganović

Published in: International endodontic journal (2018)

Type 2 diabetic participants had decreased MEL in hDP. At pharmacological concentrations, MEL is not cytotoxic for hDPCs and normalizes iNOS and SOD activity levels in hyperglyceamic hDPCs suggesting its antioxidant and protective effects in human dental pulp tissue under hyperglycaemia.

Keyphrases

endothelial cells
type diabetes
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
wound healing
nitric oxide
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
amyotrophic lateral sclerosis