Impact of short-term Dutasteride treatment on prostate-specific membrane antigen expression in a mouse xenograft model.

Benedikt KranzbühlerRosa SousaLukas PrauseIrene A BurgerNiels J RuppTullio SulserSouzan SalemiDaniel Eberli

Published in: Cancer reports (Hoboken, N.J.) (2021)

Short-term Dutasteride treatments with concentrations of 1 and 10 mg/kg significantly increase the total PSMA protein expression in a mouse LNCaP xenograft model. PSMA fluorescence intensity increases significantly even using lower daily concentrations of 0.1 mg/kg Dutasteride. Further investigations are needed to elucidate the impact of Dutasteride treatment on PSMA expression in patients.

Keyphrases

benign prostatic hyperplasia
lower urinary tract symptoms
pet ct
poor prognosis
pet imaging
prostate cancer
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
physical activity
long non coding rna
computed tomography
combination therapy
patient reported outcomes
patient reported