Clinical Relevance of Gastroesophageal Cancer Associated SNPs for Oncologic Outcome After Curative Surgery.
Jin-On JungNaita Maren WirsikHenrik NienhüserLeila PetersBeat Peter Müller-StichTimo HessVitalia SchüllerJohannes SchumacherThomas SchmidtPublished in: Annals of surgical oncology (2021)
Two intron variant SNPs of MGMT and STARD3 were identified that were significant survival predictors and may influence tumor biology. The data indicate that DNA methylation (MGMT) and malfunction of GPI anchoring (PGAP3) are distinct mechanisms that are relevant for tumor progression and relapse.
Keyphrases
- genome wide
- dna methylation
- free survival
- rectal cancer
- minimally invasive
- coronary artery bypass
- poor prognosis
- copy number
- electronic health record
- gene expression
- robot assisted
- genome wide association
- big data
- radical prostatectomy
- surgical site infection
- prostate cancer
- prognostic factors
- machine learning
- long non coding rna
- atrial fibrillation
- coronary artery disease
- deep learning