Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.

Binoy AppukuttanYuefang MaAndrew StempelLiam M AshanderDevy DeliyantiJennifer L Wilkinson-BerkaJustine R Smith

Published in: Clinical & experimental ophthalmology (2018)

Our findings in experiments on activated human retinal endothelial cells provide translational corroboration of studies in experimental models of retinal vasculopathy and support the therapeutic application of Nox4 inhibition by GKT136901 and GKT137831 in patients with retinal vascular diseases.

Keyphrases

endothelial cells
optical coherence tomography
diabetic retinopathy
high glucose
optic nerve
induced pluripotent stem cells
pluripotent stem cells