Dual-function AzuCR RNA modulates carbon metabolism.
Medha RainaJordan J AoyamaShantanu BhattBrian J PaulAixia ZhangTaylor B UpdegroveJuan Miranda-RíosGisela StorzPublished in: Proceedings of the National Academy of Sciences of the United States of America (2022)
SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.