Metoprolol for the Prevention of Acute Exacerbations of COPD.
Mark T DransfieldHelen VoelkerSurya P BhattKeith BrennerRichard CasaburiCarolyn E ComeJ Allen D CooperGerard J CrinerJeffrey L CurtisMeiLan K HanUmur HatipoğluErika S HelgesonVipul V JainRavi KalhanDavid KaminskyRobert KanerKen M KunisakiAllison A LambertMatthew R LammiSarah LindbergBarry J MakeFernando J MartinezCharlene McEvoyRalph J PanosRobert M ReedPaul D ScanlonFrank C SciurbaAnthony SmithPeruvemba S SriramWilliam W StringerJeremy A WeingartenJ Michael WellsElizabeth WestfallStephen C LazarusJohn E Connettnull nullPublished in: The New England journal of medicine (2019)
Among patients with moderate or severe COPD who did not have an established indication for beta-blocker use, the time until the first COPD exacerbation was similar in the metoprolol group and the placebo group. Hospitalization for exacerbation was more common among the patients treated with metoprolol. (Funded by the Department of Defense; BLOCK COPD ClinicalTrials.gov number, NCT02587351.).