Next-generation sequencing-based evaluation of the actionable landscape of genomic alterations in solid tumors: the "MOZART" prospective observational study.
Francesco SchettiniMarianna SiricoMarco LoddoGareth H WilliamsKeeda-Marie HardistyPaul ScorerRobert ThatcherPablo RiveraManuela MilaniCarla StrinaGiuseppina FerreroMarco UngariCristina BottinFabrizio ZanconatiNicolò de ManziniSergio AgugginiRichard TancrediElena FiorioAntonio FioravantiMaurizio ScaltritiDaniele GeneraliPublished in: The oncologist (2024)
We highlight the clinical value of molecular profiling in metastatic solid tumors using comprehensive NGS-based panels to improve treatment algorithms in situations of uncertainty and facilitate clinical trial recruitment. However, interpreting genomic alterations in a tumor type-specific manner is critical.