Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study.

Xipei WangYifan WangFen YaoShenglong ChenYating HouZhijie ZhengJinbiao LuoBinghui QiuZhanfu LiYirong WangZheng WuJinhua LanChun-Bo Chen

Published in: Drug design, development and therapy (2021)

In critically ill patients, the standard dose of 600 mg q12h was sufficient for MIC ≤2 mg/L in patients without ARC. Moreover, a 2400 mg/day 24-h continuous infusion was recommended for ARC patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
open label
prognostic factors
clinical trial
low dose
randomized controlled trial
squamous cell carcinoma
radiation therapy
study protocol
phase ii