Regulation of caries-induced pulp inflammation by NLRP3 inflammasome: A laboratory-based investigation.
Banan Al NatourFionnuala T LundyImad AboutCharlotte JeanneauYvonne DombrowskiIkhlas A El-KarimPublished in: International endodontic journal (2022)
Expression and upregulation of NLRP3 inflammasome with caries and LTA treatment suggest a role in caries-induced pulpitis. NLRP3 inhibitor attenuated the release of selective inflammatory cytokines and could be a potential treatment target that merit further investigation.