Expression of CD47 antigen in Reed-Sternberg cells as a new potential biomarker for classical Hodgkin lymphoma.

B López-PereiraA A Fernández-VelascoI Fernández-VegaD Corte-TorresC QuirósJ A VillegasP PalomoS GonzálezA P GonzálezÁ PayerT BernalM A Moro-GarcíaR Alonso-AriasS Alonso-ÁlvarezEnrique Colado

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2019)

We propose that HRS cells, by up-regulating CD47, might avoid innate immunity check on tumor growth, which could be circumvented using blocking monoclonal antibodies.

Keyphrases

induced apoptosis
hodgkin lymphoma
poor prognosis
endoplasmic reticulum stress
oxidative stress
long non coding rna
binding protein