Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion.

Christoph FrauneLuisa HarmsFranziska BüscheckDoris HöflmayerMaria Christina TsourlakisTill S ClauditzRonald SimonKatharina MöllerAndreas M LuebkeChristina Möller-KoopStefan SteurerClaudia Hube-MaggGuido SauterSören WeidemannPatrick LebokDavid DumSimon KindSarah MinnerJakob R IzbickiThorsten SchlommHartwig HulandHans HeinzerEike BurandtAlexander HaeseMarkus GraefenCornelia Schroeder

Published in: Molecular medicine (Cambridge, Mass.) (2020)

These data demonstrate that TFAP2D protein overexpression is linked to prostate cancer progression and genomic instability in ERG negative prostate cancers.

Keyphrases

prostate cancer
transcription factor
radical prostatectomy
cell proliferation
electronic health record
poor prognosis
copy number
signaling pathway
dna binding
protein protein
gene expression
machine learning
small molecule
young adults
genome wide identification