The role of palbociclib on the alterations in CDKN2, CCNE1, E2F3, MDM2 expressions as target genes of miR-141.
Mohammad Ali BaziyarArshad HosseiniFarinush JandelPublished in: PloS one (2024)
Among investigated genes, E2F3 gene was not significantly affected by Palbociclib in any of cell lines and time points. Besides, the expression of CCNE1 gene was significantly suppressed. It seems this drug was unable to reduce the expression of MDM2 gene significantly in triple negative (MDA-MB-231) cancer cells; however, a decrease was observed in luminal A (MCF-7) cells. CDKN2A and miR-141 genes expression increased significantly after treatment which can be aligned with palbociclib in proliferation inhibition.
Keyphrases
- genome wide identification
- genome wide
- poor prognosis
- long non coding rna
- cell proliferation
- genome wide analysis
- copy number
- dna methylation
- transcription factor
- induced apoptosis
- breast cancer cells
- binding protein
- metastatic breast cancer
- cell cycle arrest
- signaling pathway
- long noncoding rna
- bioinformatics analysis
- cell death
- endoplasmic reticulum stress