Operational complexity versus design efficiency: challenges of implementing a phase IIa multiple parallel cohort targeted treatment platform trial in advanced breast cancer.

Claire SnowdonSarah KernaghanLaura MorettiNicholas C TurnerAlistair RingKatie WilkinsonSue MartinStephanie FosterLucy S KilburnJudith M Bliss

Published in: Trials (2022)

Platform trial designs allow the efficient reporting of multiple treatment cohorts. Operational challenges can be overcome through multidisciplinary engagement, streamlined contracting processes, rationalised protocol and database design and appropriate resourcing.

Keyphrases

clinical trial
study protocol
randomized controlled trial
high throughput
phase iii
quality improvement
adverse drug
emergency department
drug delivery
cancer therapy
replacement therapy