Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4.
Akihiro KimuraTakeshi TakagiThiprampai ThamamongoodSatoshi SakamotoTakumi ItoIwao SekiMasahiro OkamotoHiroyuki AonoSatoshi SeradaTetsuji NakaHiroaki ImatakaKensuke MiyakeTakuya UedaMiki MiyanokoshiKeisuke WakasugiNoriko IwamotoNorio OhmagariTakahiro IguchiTakeshi NittaHiroshi TakayanagiHiroyuki YamashitaHiroshi KanekoHaruka TsuchiyaKeishi FujioHiroshi HandaHarumi SuzukiPublished in: Annals of the rheumatic diseases (2023)
Our findings uncovered the significant role of aaRSs as a novel alarmin in RA pathogenesis, indicating that their blocking agents are potent antirheumatic drugs.