Adjunctive Lumateperone (ITI-007) in the Treatment of Bipolar Depression: Results From a Randomized Placebo-Controlled Clinical Trial.

Trisha SuppesSuresh DurgamSusan G KozauerRichard ChenHassan D LakkisRobert E DavisAndrew SatlinKimberly E VanoverSharon MatesRoger S McIntyre Mauricio Tohen

Published in: Bipolar disorders (2023)

Lumateperone 42-mg treatment adjunctive to lithium or valproate significantly improved depression symptoms and was generally well tolerated in patients with MDEs associated with either bipolar I or bipolar II disorder.

Keyphrases

clinical trial
bipolar disorder
depressive symptoms
sleep quality
double blind
randomized controlled trial
combination therapy
replacement therapy
phase ii study