Bacterial Biofilm Components Induce an Enhanced Inflammatory Response Against Metal Wear Particles.
Ulrike DapuntBirgit PriorJan Philippe KretzerThomas GieseYina ZhaoPublished in: Therapeutics and clinical risk management (2020)
We were able to show that minor amounts of bacterial components and metal wear particles together induce an enhanced inflammatory response in human monocytes and osteoblasts. This effect could significantly contribute to the generation of bone-resorbing osteoclasts and hence implant-loosening.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- toll like receptor
- endothelial cells
- soft tissue
- bone loss
- pseudomonas aeruginosa
- staphylococcus aureus
- bone mineral density
- induced pluripotent stem cells
- candida albicans
- dendritic cells
- pluripotent stem cells
- peripheral blood
- cystic fibrosis
- body composition
- immune response