Neurofilament Light in CSF and Plasma Is a Marker of Neuronal Damage in HTLV-1-Associated Myelopathy and Correlates With Neuroinflammation.
Carolina RosadasHenrik ZetterbergAmanda HeslegraveJana HaddowMina BorisovaGraham P TaylorPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
Nf-L in plasma and CSF has potential to be used as a biomarker of disease activity in HAM. Neuronal damage seems to be more intense early in disease but persists long term. Wheelchair-dependent patients have ongoing neuroinflammation.
Keyphrases
- disease activity
- lps induced
- rheumatoid arthritis
- systemic lupus erythematosus
- cerebral ischemia
- end stage renal disease
- oxidative stress
- traumatic brain injury
- ejection fraction
- newly diagnosed
- rheumatoid arthritis patients
- cerebrospinal fluid
- lipopolysaccharide induced
- chronic kidney disease
- ankylosing spondylitis
- spinal cord
- signaling pathway
- prognostic factors
- inflammatory response
- peritoneal dialysis
- risk assessment
- immune response
- toll like receptor
- nuclear factor
- human health