NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer.
Szymon J SzymuraJacob P ZaemesDavid F AllisonSheena H CliftJaclyn M D'InnocenziLisa G GrayBrian D McKennaBenjamin B MorrisStefan BekiranovRobin D LeGalloDavid R JonesMarty W MayoPublished in: Cell communication and signaling : CCS (2019)
Consistent with GFPT2 promoting cancer progression, we find that elevated GFPT2 expression correlates with poor clinical outcome in NSCLC. Modulation of GFPT2 activity offers a potentially important therapeutic target to combat NSCLC disease progression.