Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy.
Yinhui WangJia SongKun YuDaan NieChengcheng ZhaoLiping JiaoZiyi WangLing ZhouFeng WangQilin YuShu ZhangZheng WenJunfang WuCong-Yi WangDao-Wen WangJia ChengChunxia ZhaoPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
This study demonstrated that IDO1 deficiency and consequent Kyn insufficiency can protect against pathological cardiac hypertrophy by decreasing GATA4 expression in an AhR-dependent manner.